Adoptively transferred Tregs accumulate in a site-specific manner and ameliorate signs of less advanced collagen-induced arthritis progress in rats-Reference-Cited by-同舟云学术

Adoptively transferred Tregs accumulate in a site-specific manner and ameliorate signs of less advanced collagen-induced arthritis progress in rats

Published:2015-03 Issue:3 Volume:7 Page:215-228
ISSN:1750-743X
Container-title:Immunotherapy
language:en
Short-container-title:Immunotherapy

Author:

Felcenloben Isaura¹,Piasecki Tomasz²,Miller Julia¹,Rossowska Joanna³,Bańcyr Edyta¹,Atamaniuk Wojciech⁴,Nowak Marcin⁴,Świerkot Jerzy⁵,Ratajczak Kornel⁶,Chełmońska-Soyta Anna¹³

Affiliation:

1. Wroclaw University of Environmental & Life Science, Faculty of Veterinary Medicine, Department of Immunology, Pathophysiology & Prevention Veterinary, Norwida 31, 50-375 Wroclaw, Poland

2. Wroclaw University of Environmental & Life Science, Faculty of Veterinary Medicine, Department of Epizootiology & Clinic of Birds & Exotic Animals, Grunwaldzki 45, 50-366 Wroclaw, Poland

3. Ludwik Hirszfeld Institute of Immunology & Experimental Therapy Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland

4. Wroclaw University of Environmental & Life Science, Faculty of Veterinary Medicine, Department of Pathology, Norwida 31, 50-375 Wroclaw, Poland

5. Wroclaw Medical University, Faculty of Medicine, Department & Clinic of Rheumatology & Internal Medicine, Borowska 213, 50-556 Wroclaw, Poland

6. Poznan University of Life Sciences; Veterinary Institute, Wolynska 35, 60-637 Poznan, Poland

Abstract

Aim: The aim of the study was to assess the therapeutic effect and migration of adoptively transferred Tregs in the course of collagen-induced arthritis (CIA) in rats. Methods: Sorted CD4+CD25+ cells were cultured in the presence of 17-β-estradiol, stained with CellTracker and then administered into the articular capsule of ankle joint of animals in different stages of CIA progression. Results: Tregs diminished CIA signs only in animals with less advanced disease progress. Moreover, migration of transferred cells into the LN in the near proximity of the injection site and with distal location was almost completely stopped in animals with fully developed CIA. Conclusion: Disease progression-related differences in migratory potential of in vitro induced Tregs may be responsible for the failure of cellular therapy during the advanced stages of CIA.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

Link

https://www.futuremedicine.com/doi/pdf/10.2217/imt.14.121

Reference38 articles.

1. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease.

2. Control of Regulatory T Cell Development by the Transcription Factor Foxp3

3. CD4+CD25+ Immunoregulatory T Cells

4. CTLA-4 Control over Foxp3 + Regulatory T Cell Function

5. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

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