Immunotherapeutic approaches to improve graft-versus-tumor effect and reduce graft-versus-host disease

Author:

Tsirigotis Panagiotis1,Or Reuven2,Resnick Igor B2,Shapira Michael-Yechiel2

Affiliation:

1. 2nd Dept of Internal Medicine, Hematology Unit, ‘ATTIKON’ General Hospital Medical School, University of Athens, Rimini-1, Haidari, PO 12462, Greece.

2. Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah – Hebrew University Medical Center, Jerusalem, Israel

Abstract

The therapeutic efficacy of allogeneic stem cell transplantation is mainly based on the alloreactive immune response of the graft against the host. However, the graft-versus-host process can be viewed as a double-edged sword since it is responsible for both the beneficial graft-versus-tumor effect and the deleterious graft-versus-host disease. During the last two decades, intensive research has been focused on the development of novel immunotherapeutic methods aimed to dissociate graft-versus-host disease from graft-versus-tumor effect. A brief description of these efforts is discussed in this review.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

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