Surface tension and intrinsic amyloid fluorescence of serum and cerebrospinal fluid samples in Alzheimer´s disease

Author:

Gazova Zuzana1,Bednarikova Zuzana1,Bartos Ales23,Klaschka Jan4,Kristofikova Zdenka2

Affiliation:

1. Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Kosice, Slovakia

2. National Institute of Mental Health, Topolova 748, 250 67 Klecany, Czech Republic

3. Third Faculty of Medicine, University Hospital Kralovske Vinohrady, Charles University, Srobarova 50, 100 34 Prague 10, Czech Republic

4. Institute of Computer Science, Czech Academy of Sciences, Pod vodarenskou vezi 271/2, 182 07 Prague 8, Czech Republic

Abstract

Aim: Surface tension of biological fluids can be influenced by changes in oligomerization or aggregation of surfactant peptides or proteins. Amphiphilic peptides of amyloid-β or other amyloidogenic peptides/proteins display properties of surfactants, oligomerization and aggregation increase also their fluorescence intensity compared with native structures. Results/methodology: We estimated surface tension and native/ThioflavinT-based/intrinsic amyloid fluorescence intensity in serum and cerebrospinal fluid samples for their evalution as diagnostic biomarkers for Alzheimer´s disease (AD). Discussion/conclusion: Our results indicate that values of surface tension are not a suitable biomarker for AD. However, the ratio of ThioflavinT-based fluorescence to intrinsic amyloid fluorescence in cerebrospinal fluid appears to be an acceptable supportive diagnostic biomarker for AD (its sensitivity was 61.1%, and the specificity 70.8% when compared with aged controls).

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

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