Reproducibility of novel immune-inflammatory biomarkers over 4 months: an analysis with repeated measures design-Reference-Cited by-同舟云学术

Reproducibility of novel immune-inflammatory biomarkers over 4 months: an analysis with repeated measures design

Published:2019-06 Issue:8 Volume:13 Page:639-648
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Schenk Matthew¹,Eichelmann Fabian¹,Schulze Matthias B²³⁴⁵,Rudovich Natalia³⁶⁷⁸,Pfeiffer Andreas F³⁶⁷,di Giuseppe Romina⁹,Boeing Heiner¹⁰,Aleksandrova Krasimira¹⁵

Affiliation:

1. Senior Scientist Group Nutrition, Immunity & Metabolism, Department of Nutrition & Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

2. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

3. German Centre for Diabetes Research, Germany

4. DZHK (German Centre for Cardiovascular Research), partner site Berlin, Berlin, Germany

5. University of Potsdam, Institute of Nutritional Science, Potsdam, Germany

6. Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

7. Department of Endocrinology, Diabetes & Nutrition, Campus Benjamin Franklin, Charité University Medicine, Berlin, Germany

8. Division of Endocrinology & Diabetes, Department of Internal Medicine, Spital Bülach, Bülach, Switzerland

9. Institute of Epidemiology, Christian-Albrechts University Kiel, Kiel, Germany

10. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

Abstract

Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-β, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-β (0.75 [95% CI: 0.33–0.90]) to excellent for MMF (0.81 [95% CI: 0.64–0.90]), clusterin (0.83 [95% CI: 0.78–0.87]) and suPAR (0.91 [95% CI: 0.88–0.93]). Measurement of TGF-β was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0351

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