The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers-Reference-Cited by-同舟云学术

The relationship between CYP7A1 polymorphisms, coronary artery disease & serum lipid markers

Published:2019-10 Issue:14 Volume:13 Page:1199-1208
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Iwanicki Tomasz¹,Balcerzyk Anna¹,Niemiec Paweł¹,Trautsolt Wanda²,Grzeszczak Władysław²,Ochalska-Tyka Anna³,Krauze Jolanta⁴,Nowak Tomasz¹,Żak Iwona¹

Affiliation:

1. Department of Biochemistry & Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia, Medykow Street 18, 40-752 Katowice, Poland

2. Department of Internal Medicine, Diabetes & Nephrology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, 3 Maja Street 13–18, 41-800 Zabrze, Poland

3. Regional Centre of Blood Donation & Blood Treatment in Raciborz, Sienkiewicza Street 3, 47-400 Raciborz, Poland

4. 1st Department of Cardiac Surgery in Upper Silesian Center of Cardiology in Katowice, School of Medicine in Katowice, Medical University of Silesia, Ziolowa Street 47, 40-635 Katowice, Poland

Abstract

Polymorphic variants of the CYP7A1 gene can increase the risk of atherosclerosis-based coronary artery disease (CAD) and modify serum lipid markers. Method: We studied haplotype-tagging single nucleotide polymorphisms of CYP7A1 in the Caucasian population and if they are associated with CAD, its symptoms, and any of its risk factors. Results: We did not find the genetic variants of CYP7A1 to be associated with an increased risk of CAD. However, we did find that the common rs3808607 variant is associated with modified concentrations of serum total cholesterol and LDL. We also found that the C allele and the CC genotype of the rs11786580 are more frequent in patients with myocardial infarction. This association was especially strong after the group differentiation by sex.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0462

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