Evaluation of homocysteine in the diagnosis and prognosis of coronary slow flow syndrome-Reference-Cited by-同舟云学术

Evaluation of homocysteine in the diagnosis and prognosis of coronary slow flow syndrome

Published:2019-12 Issue:17 Volume:13 Page:1439-1446
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Li Nan¹²,Tian Liuyang¹³,Ren Jiefeng¹,Li Yang¹,Liu Yuqi¹⁴⁵⁶^ORCID

Affiliation:

1. Cardiac Department, PLA General Hospital, Beijing 100853, PR China

2. Cardiac Department, Teda International Cardiovascular Hospital, Tianjin 300457, PR China

3. Cardiac Department, Tianjin People's Hospital, Tianjin 300121, PR China

4. Department of Cardiology & National Clinical Research Center of Geriatrics Disease, Chinese PLA General Hospital, Beijing 100853, PR China

5. Beijing Key Laboratory of Chronic Heart Failure Precision Medicine, Cardiac department, Chinese PLA General Hospital, Beijing 100853, PR China

6. National Key Laboratory of Kidney Diseases, Cardiac department, Chinese PLA General Hospital, Beijing 100853, PR China

Abstract

Aim: To identify the exact molecular markers related to coronary slow flow syndrome (CSFS) and its prognosis. Patients & methods: Data from 54 patients with CSFS diagnosed by coronary angiography and 101 normal control patients were collected and analyzed. Results: Logistic regression analysis confirmed that homocysteine (Hcy; odds ratio: 1.107; 95% CI: 1.018–1.205; p = 0.018) was associated with CSFS. Receiver-operating characteristic curve analysis identified an Hcy value of 17.1 μmol/l as an effective cut-off point for predicting CSFS. Cox survival analysis showed a relationship between high admission Hcy level (odds ratio: 1.19; 95% CI = 1.05–1.34; p = 0.005) and recurrent angina. Conclusion: Our results showed positive correlations of Hcy with CSFS and cardiac events.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0446

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