NT-proBNP plasma levels as biomarkers for pulmonary hypertension in healthy infants with respiratory syncytial virus infection-Reference-Cited by-同舟云学术

NT-proBNP plasma levels as biomarkers for pulmonary hypertension in healthy infants with respiratory syncytial virus infection

Published:2019-06 Issue:8 Volume:13 Page:605-618
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Rodriguez-Gonzalez Moises¹²,Benavente-Fernandez Isabel²³,Castellano-Martinez Ana²⁴,Lechuga-Sancho Alfonso Maria²⁵,Lubian-Lopez Simon Pedro²³

Affiliation:

1. Pediatric Cardiology Department, Puerta del Mar University Hospital, Cádiz, Spain

2. Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit of Puerta del Mar University Hospital, University of Cádiz, Spain

3. Neonatology Department, Puerta del Mar University Hospital, Cádiz, Spain

4. Pediatric Nephrology Department, Puerta del Mar University Hospital, Cádiz, Spain

5. Maternal and Child Health and Radiology Department, School of Medicine, University of Cádiz, Spain

Abstract

Aim: To explore NT-proBNP as biomarker for pulmonary hypertension (PH) in infants with respiratory syncytial virus infection (RSVI). Patients & methods: We prospectively enrolled 93 healthy infants with RSVI aged 1–12 months. NT-proBNP determination and echocardiography were performed at admission. Results: PH was found in 22% of patients and associated with a severe course of the disease. NT-proBNP >1635 pg/ml resulted an independent predictor for PH (odds ratio: 16.46 [95% CI: 4.10–66; p < 0.001]). The diagnostic performance of NT-proBNP to detect PH in RSVI was high (area under receiver operator curve of 0.932 [95% CI: 0.883–0.981; p < 0.001]). Conclusions: The presence of PH in healthy infants with RSVI is associated with worse outcomes. NT-proBNP resulted an accurate biomarker for PH in this setting.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0348

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