CD44 epithelial isoform inversely associates with invasive characteristics of colorectal cancer-Reference-Cited by-同舟云学术

CD44 epithelial isoform inversely associates with invasive characteristics of colorectal cancer

Published:2019-04 Issue:6 Volume:13 Page:419-426
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Sadeghi Asieh¹,Roudi Raheleh¹,Mirzaei Alireza²,Zare Mirzaei Ali³,Madjd Zahra¹⁴,Abolhasani Maryam¹⁵

Affiliation:

1. Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran

2. Bone & Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran

3. Department of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

4. Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

5. Department of Pathology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran

Abstract

Aim: There is no consensus regarding the clinical significance of CD44 and CD24 as cancer stem cell (CSC) marker in colorectal cancer (CRC). Methodology: A total of 494 CRC samples (2008–2017) were assessed for CD44 (epithelial isoform) and CD24 expression using tissue microarray. Results: CD24 individually or in combination with CD44 was not associated with any of the clinicopathologic characteristics of the tumor. CD44 expression was inversely associated with pathological Tumor, Node, Metastasis (pTNM) lower stages (p = 0.038) and lymphatic invasion (p = 0.05). Conclusion: In summary, the epithelial isoform of CD44 is inversely associated with invasive characteristics of CRC.

Publisher

Future Medicine Ltd

Subject

Biochemistry, medical,Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0337

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