Association between AXIN1 gene polymorphisms and epithelial ovarian cancer in Chinese population-Reference-Cited by-同舟云学术

Association between AXIN1 gene polymorphisms and epithelial ovarian cancer in Chinese population

Published:2019-04 Issue:6 Volume:13 Page:445-455
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Zhang Yan¹²,Wang Yanyun²,Huang Xingming¹²,Li Qin²³,Li Kai²⁴,You Di²⁵,Song Yaping²,Su Min²,Zhou Bin²,Wang Wei¹

Affiliation:

1. Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China

2. Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects & Related Diseases of Women & Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China

3. Department of Immunology, West China School of Preclinical & Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, PR China

4. Department of Cardiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, PR China

5. Department of Obstetrics & Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China

Abstract

Aim: The study was aimed to explore the association between AXIN1 gene polymorphism and epithelial ovarian cancer (EOC) susceptibility as well as prognosis. Methods: A total of 165 EOC cases and 327 healthy controls were recruited to participate in this study. In total three tag SNPs in AXIN1 gene were genotyped using PCR-restriction fragment length polymorphism. Results: Significantly increased EOC risk was found associated with the A/C heterozygous genotype of rs12921862, the C allele and C/T genotype in the rs1805105 and the T/T genotype of rs370681. Meanwhile, Kaplan–Meier survival curves showed that patients with rs12921862 C/C genotype improved overall survival in the EOC group. Conclusion: Our results suggest that the AXIN1 gene may be related to susceptibility and overall survival in EOC.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0306

Reference38 articles.

1. The Cell of Origin of Ovarian Epithelial Tumors and the Ovarian Surface Epithelium Dogma: Does the Emperor Have No Clothes?

2. Cytokines and Prognostic Factors in Epithelial Ovarian Cancer

3. Identification of six new susceptibility loci for invasive epithelial ovarian cancer

4. TP53 mutations are common in all subtypes of epithelial ovarian cancer and occur concomitantly with KRAS mutations in the mucinous type

5. The variations in the AXIN1 gene and susceptibility to cryptorchidism

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