RAB27A is an independent prognostic factor in clear cell renal cell carcinoma-Reference-Cited by-同舟云学术

RAB27A is an independent prognostic factor in clear cell renal cell carcinoma

Published:2019-03 Issue:4 Volume:13 Page:239-247
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

An Hyo Jung¹²,Song Dae Hyun²³⁴,Koh Hyun Min²,Ko Gyung Hyuck³⁴⁵,Lee Jeong-Hee³⁴⁵,Kim Dong Chul³⁴⁵,Yang Jung Wook⁵,Kim Min Hye¹⁵,Seo Deok Ha¹⁶,Jang Se Min⁷,Lee Jong Sil³⁴⁵

Affiliation:

1. Department of Medicine, Gyeongsang National University College of Medicine, Jinju, Korea

2. Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea

3. Gyeongsang National University School of Medicine, Jinju, Korea

4. Gyeongsang Institute of Health Science, Jinju, Korea

5. Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea

6. Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Korea

7. Department of Pathology, Konyang University Hospital, Daejeon, Korea

Abstract

Aim: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). Materials & methods: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. Results: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128–41.241; p-value = 0.036). Conclusion: RAB27A is an independent prognostic factor in CCRCC.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2018-0336

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