Prognostic value of alkaline phosphatase and gamma-glutamyl transferase in patients with metastatic pancreatic cancer-Reference-Cited by-同舟云学术

Prognostic value of alkaline phosphatase and gamma-glutamyl transferase in patients with metastatic pancreatic cancer

Published:2023-04 Issue:13 Volume:19 Page:937-946
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Catalano Martina¹^ORCID,Roviello Giandomenico¹^ORCID,Aprile Giuseppe²,Ramello Monica³,Conca Raffaele⁴,Petrioli Roberto⁵,Perrone Gabriele¹,Ianza Anna³,Mini Enrico¹

Affiliation:

1. Department of Health Sciences, University of Florence, 50139, Florence, Italy

2. Department of Oncology, San Bortolo General Hospital, AULSS8 Berica, Vicenza, Italy

3. Oncology Unit, Department of Medical, Surgical, & Health Sciences, University of Trieste, Piazza Ospitale, Trieste, Italy

4. Division of Medical Oncology, Department of Onco-Hematology, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028, Rionero, Vulture (PZ), Italy

5. Department of Medicine, Surgery & Neurosciences, Medical Oncology Unit, University of Siena, 53100, Siena, Italy

Abstract

Background: Pancreatic cancer (PC) is one of the most lethal malignancies worldwide. This study evaluated the prognostic role of serum alanine phosphatase (ALP) and gamma-glutamyl-transferase (GGT) in metastatic PC patients. Materials & methods: 153 patients with metastatic PC receiving first-line treatment with nab-paclitaxel/gemcitabine were retrospectively enrolled in a multicenter study and stratified according to ALP (≤ or >260 U/l) and GGT (≤ or >45.5 U/l) levels. Results: Improved overall survival was recorded in patients with GGT levels ≤45.5 U/l (p < 0.05). In patients with liver metastasis, overall survival was significantly lower in patients with high ALP (p = 0.01) and GGT (p = 0.02). Conclusion: High levels of ALP and GGT were related to a poor prognosis in PC patients with liver metastasis receiving nab-paclitaxel/gemcitabine.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2023-0137

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