Genetic markers of chronic lymphocytic leukemia: a retrospective study of 312 patients from a reference center in Lebanon-Reference-Cited by-同舟云学术

Genetic markers of chronic lymphocytic leukemia: a retrospective study of 312 patients from a reference center in Lebanon

Published:2023-09 Issue:29 Volume:19 Page:1991-2002
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Ayoub Georges¹,Sinan Hassan²,Kourie Hampig Raphael³,Kattan Joseph³,Nasr Fadi³,Karak Fadi el³,Wakim Jad³,Ghosn Marwan³,Chahine Georges³,Farra Chantal⁴,Chebly Alain⁵⁶^ORCID

Affiliation:

1. Faculty of Medicine, Saint Joseph University of Beirut, Lebanon

2. Faculty of Medicine, American University of Beirut, Lebanon

3. Department of Hematology-Oncology, Hotel-Dieu de France University Hospital, Beirut, Lebanon

4. Medical Genetics Unit, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon, till march 2022

5. Jacques Loiselet Center for Medical Genetics & Genomics (CGGM), Faculty of Medicine, Saint Joseph University, Beirut, Lebanon

6. Higher Institute of Public Health, Saint Joseph University, Beirut, Lebanon

Abstract

Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values – mainly immunoglobulin heavy chain variable region gene ( IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2023-0535

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