NMDA antagonists as Parkinson’s disease therapy: disseminating the evidence-Reference-Cited by-同舟云学术

NMDA antagonists as Parkinson’s disease therapy: disseminating the evidence

Published:2014-02 Issue:1 Volume:4 Page:23-30
ISSN:1758-2024
Container-title:Neurodegenerative Disease Management
language:en
Short-container-title:Neurodegenerative Disease Management

Author:

Majláth Zsófia¹,Vécsei László²

Affiliation:

1. Department of Neurology, University of Szeged, Semmelweis utca 6, H-6725 Szeged, Hungary

2. Neuroscience Research Group of the Hungarian Academy of Sciences & University of Szeged, Semmelweis utca 6, H-6725 Szeged, Hungary.

Abstract

SUMMARY Oral levodopa is the current baseline therapy in the management of Parkinson’s disease, but nonmotor complications and therapy-related dyskinesias pose an important challenge for clinicians. Glutamate receptors have been implicated in the neurodegenerative process of Parkinson’s disease and also in the development of levodopa-induced dyskinesias. This article discusses the role of NMDA receptors in Parkinson’s disease and their modulation as a possible therapeutic approach.

Publisher

Future Medicine Ltd

Subject

Neurology (clinical)

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nmt.13.77

Reference64 articles.

1. Impulse control disorders in Parkinson's disease: prevalence and possible risk factors

2. Targeting Glutamate Receptors to Tackle the Pathogenesis, Clinical Symptoms and Levodopa-Induced Dyskinesia Associated with Parkinson’s Disease

3. Levodopa-induced dyskinesia in Parkinson's disease: clinical features, pathogenesis, prevention and treatment

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