Ceruloplasmin expression in renal cell carcinoma correlates with higher-grade and shortened survival-Reference-Cited by-同舟云学术

Ceruloplasmin expression in renal cell carcinoma correlates with higher-grade and shortened survival

Published:2021-08 Issue:11 Volume:15 Page:841-850
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Zimpfer Annette¹^ORCID,Glass Änne²,Bastian Manuela³,Schuff-Werner Peter³,Hakenberg Oliver W⁴,Maruschke Matthias⁴⁵

Affiliation:

1. Institute of Pathology, University Medicine Rostock, Strempelstr 14, Rostock, 18055, Germany

2. Institute for Biostatistics & Informatics in Medicine, University Medicine Rostock, Ernst-Heydemann-Str 8, Rostock, 18057, Germany

3. Institute of Clinical Chemistry & Laboratory Medicine, University Medicine Rostock, Ernst-Heydemann-Straße 6, Rostock,18057, Germany

4. Department of Urology, University Medicine Rostock, Ernst-Heydemann-Str 8, Rostock, 18057, Germany

5. Department of Urology, HELIOS Hanseklinikum Stralsund, Große Parower Str 47-53, Stralsund, 18435, Germany

Abstract

Aim: We aimed to explore ceruloplasmin (CP) expression in clear cell renal cell carcinoma (ccRCC). Materials & methods: CP was analyzed in biofluid samples of 63 ccRCC patients, divided into three grading groups, and immunohistochemically, in 308 ccRCC. Results: Significant differences of mean plasma and urine CP levels in different grading groups were found. CP immunoreactivity was significantly linked to high-grade disease. Log rank tests showed a significant shorter overall survival rate in CP-positive cases (all p < 0.05). Conclusion: CP protein levels in biofluid samples confirmed differential CP expressions, depending on nuclear grade in ccRCC as previously seen in RNA expression analysis. CP expression was linked to high-grade disease and reduced survival rate in RCC.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2020-0514

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