Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer-Reference-Cited by-同舟云学术

Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer

Published:2020-10 Issue:14 Volume:14 Page:1371-1382
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Vermani Litika¹,Kumar Rajeev²^ORCID,Kannan Rengaswamy R²,Deka Monoj K³,Talukdar Anuradha²,Kumar Nachimuthu S¹

Affiliation:

1. Mizoram University, Biotechnology, Aizawl, Mizoram 796004, India

2. Cachar Cancer Hospital & Research Centre, Research Silchar, 788015, India

3. Silchar Medical College & Hospital, 788015, India

Abstract

Aim: To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age. Materials & methods: Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples. Results: ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001). Conclusion: High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2020-0206

Reference51 articles.

1. Meeting report from the joint IARC–NCI international cancer seminar series: a focus on colorectal cancer

2. The IARC Perspective on Colorectal Cancer Screening

3. Biomarker targeting of colorectal cancer stem cells

4. Colorectal cancer statistics, 2017

5. Increasing Incidence of Colorectal Cancer in Adolescents and Young Adults Aged 15–39 Years in Western Australia 1982–2007: Examination of Colonoscopy History

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Wnt/β-catenin signalling, epithelial-mesenchymal transition and crosslink signalling in colorectal cancer cells;Biomedicine & Pharmacotherapy;2024-06

2. Role of epithelial-to-mesenchymal transition and cancer stem cells in colorectal cancer;Oncology in Clinical Practice;2024-05-31

3. Identification of differentially expressed genes and splicing events in early-onset colorectal cancer;Frontiers in Oncology;2024-04-11

4. Fenofibrate suppresses the progression of hepatoma by downregulating osteopontin through inhibiting the PI3K/AKT/Twist pathway;Naunyn-Schmiedeberg's Archives of Pharmacology;2023-08-11

5. Fenofibrate suppresses the progression of hepatoma by inhibiting PI3K/AKT/Twist pathway through downregulating Osteopontin;2023-05-08