Novel kidney injury biomarkers in a large cohort of children with sickle cell anemia-Reference-Cited by-同舟云学术

Novel kidney injury biomarkers in a large cohort of children with sickle cell anemia

Published:2021-08 Issue:12 Volume:15 Page:999-1009
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Belisário André R¹²³^ORCID,S Filha Roberta da²,de Almeida Jéssica A²,Mendes Fabíola G²,Rezende Paulo V³⁴,Vieira Érica LM²,e Silva Ana CS²^ORCID

Affiliation:

1. Centro de Tecidos Biológicos de Minas Gerais, Fundação Hemominas, Lagoa Santa, Minas Gerais, 33400000, Brazil

2. Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, 30130100, Brazil

3. Faculdade de Medicina/Núcleo de Ações e Pesquisa em Apoio Diagnóstico (NUPAD), UFMG, Belo Horizonte, Minas Gerais, 30130100, Brazil

4. Ambulatório do Hemocentro de Belo Horizonte, Fundação Hemominas, Belo Horizonte, Minas Gerais, 30130110, Brazil

Abstract

Aim: The aim of this study was to compare novel kidney injury biomarkers in sickle cell anemia (SCA) children with and without albuminuria or glomerular hyperfiltration. Materials & methods: A total of 358 Brazilian children with SCA were studied. Fifteen kidney injury biomarkers in urine were measured. Albuminuria was defined as urine albumin/creatinine ratio >100 mg/g. Glomerular hyperfiltration was defined as estimated glomerular filtration rate ≥140 ml/min/1.73 m2. Results: After adjustment for age, sex and modifying therapies in use, EGF and collagen IV urinary levels were associated with albuminuria. Renin and clusterin levels were associated with hyperfiltration. Conclusion: Levels of novel kidney injury biomarkers were associated with albuminuria and hyperfiltration in Brazilian children with SCA, suggesting concomitant structural and functional abnormalities.

Funder

Fundação de Amparo à Pesquisa de Minas Gerais

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2020-0769

Reference39 articles.

1. Sickle cell disease

2. Sickle Cell Disease

3. Sickle cell disease: renal manifestations and mechanisms

4. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG)

5. Hyperfiltration during early childhood precedes albuminuria in pediatric sickle cell nephropathy

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Urinary angiotensinogen is associated with albuminuria in adults with sickle cell anaemia;British Journal of Haematology;2023-05-15