Identification of prognosis-associated immune genes and exploration of immune cell infiltration in colorectal cancer-Reference-Cited by-同舟云学术

Identification of prognosis-associated immune genes and exploration of immune cell infiltration in colorectal cancer

Published:2020-10 Issue:14 Volume:14 Page:1353-1369
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Miao Yan-Dong¹^ORCID,Wang Jiang-Tao¹^ORCID,Yang Yuan¹,Ma Xue-Ping²,Mi Deng-Hai¹³^ORCID

Affiliation:

1. The First Clinical Medical College of Lanzhou University, Lanzhou City, Gansu Province, PR China

2. Second People's Hospital of Gansu Province, Lanzhou City, Gansu Province, PR China

3. Gansu Academy of Traditional Chinese medicine, Lanzhou City, Gansu Province, PR China

Abstract

Aim: To identify prognosis-related immune genes (PRIGs) and construct a prognosis model of colorectal cancer (CRC) patients for clinical use. Materials & methods: Expression profiles were obtained from The Cancer Genome Atlas database and identified differentially expressed PRIGs of CRC. Results: A prognostic model was conducted based on nine PRIGs. The risk score, based on prognosis model, was an independent prognostic predictor. Five PRIGs and risk score were significantly associated with the clinical stage of CRC and five immune cells related to the risk score. Conclusion: The risk score was an independent prognostic biomarker for CRC patients. The research excavated immune genes that were associated with survival and that could be potential biomarkers for prognosis and treatment for CRC patients.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2020-0024

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