Efficacy and safety of ezetimibe plus atorvastatin therapy

Author:

Foody JoAnne M1,Toth Peter P23,Tershakovec Andrew M4,Musliner Thomas4,Tomassini Joanne E4,Lowe Robert S4,Neff David R4,Davis Harry R4

Affiliation:

1. Cardiovascular Wellness Program, Brigham and Women’s Hospital, PB-136, Boston, MA 02115, USA

2. CGH Medical Center, Sterling, IL 61081, USA

3. University of Illinois College of Medicine, Peoria, IL 61605, USA

4. Merck Sharp & Dohme Corp., Whitehouse Station, NJ 08889, USA

Publisher

Informa UK Limited

Subject

Cardiology and Cardiovascular Medicine,Endocrinology, Diabetes and Metabolism

Reference220 articles.

1. Baigent C, Blackwell L, Emberson J et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376(9753), 1670–1681 (2010). •• Largest meta-analysis of 26 randomized controlled statin trials, including intensive treatment, showing that the magnitude of LDL lowering is related to the reduction of cardiovascular events.

2. Baigent C, Keech A, Kearney PM et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 366(9493), 1267–1278 (2005).

3. Robinson JG, Smith B, Maheshwari N, Schrott H. Pleiotropic effects of statins: benefit beyond cholesterol reduction? A meta-regression analysis. J. Am. Coll. Cardiol. 46(10), 1855–1862 (2005). • Meta-analysis of 18 intervention trials showing the relationship between statin and nonstatin lipid-lowering therapies with cardiovascular risk reduction.

4. Anderson TJ, Gregoire J, Hegele RA et al. 2012 update of the Canadian Cardiovascular Society guidelines for the diagnosis and treatment of dyslipidemia for the prevention of cardiovascular disease in the adult. Can. J. Cardiol. 29(2), 151–167 (2013).

5. Teramoto T, Sasaki J, Ishibashi S et al. Executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan: 2012 Version. J. Atheroscler. Thromb. 20(6), 517–523 (2013).

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