Impact of anemia management with EPO on psychologic distress in cancer patients: results of a multicenter patient survey-Reference-Cited by-同舟云学术

Impact of anemia management with EPO on psychologic distress in cancer patients: results of a multicenter patient survey

Published:2014-01 Issue:1 Volume:10 Page:69-78
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Del Prete Salvatore¹,Cinieri Saverio²,Lorusso Vito³,Maiorino Luigi⁴,Pizza Carmine⁵,Pisano Agata⁶,Montesarchio Vincenzo⁷,Leo Luigi⁸,Savastano Clementina⁹,Pistolese Giuseppe¹⁰,Bianco Maddalena¹¹,Mabilia Roberto¹²,Tonachella Riccardo¹³,Febbraro Antonio¹⁴,Manzione Luigi¹⁵,Palazzo Salvatore¹⁶,Filippelli Gianfranco¹⁷,Vincenzi Bruno¹⁸,Barbato Enrico¹⁹,Cennamo Gregorio²⁰,Riccardi Ferdinando²¹,Misso Gabriella²²,Caraglia Michele²³,Addeo Raffaele²⁴

Affiliation:

1. Salvatore Del Prete, Medical Oncology Division, ‘San Giovanni di Dio’ Frattamaggiore Hospital, ASLNA2 NORD, Naples, Italy

2. Saverio Cinieri, Medical Oncology Division & Breast Unit, A Perrino Hospital, Brindisi, Italy

3. Vito Lorusso, Medical Oncology Unit, Vito Fazzi Hospital, Lecce, Italy

4. Maiorino Luigi, Oncology Unit ‘San Gennaro’ Hospital, ASLNA1 Naples, Italy

5. Carmine Pizza, Medical Oncology Division, ‘S. Maria della Pieta’, ASLNA3 SUD Nola, Italy

6. Agata Pisano, Medical Oncology ‘San Maria delle Grazie’ Pozzuoli Hospital, ASLNA2 NORD, Naples, Italy

7. Vincenzo Montesarchio, Medical Oncology Division, ‘Cotugno’ Hospital AORN dei Colli, Naples, Italy

8. Luigi Leo, Oncology Unit, Day Hospital, Piedimonte Matese Hospital, ASLCE Caserta, Italy

9. Clementina Savastano, Medical Oncology, AORN ‘Ruggi d’Aragona’, Salerno, Italy

10. Giuseppe Pistolese, Hematology Department, AORN ‘Ruggi d’Aragona’, Salerno, Italy

11. Maddalena Bianco, Oncology Unit ‘San Leonardo’ Hospital, Castellammare di Stabia, ASL NA3SUD, Naples, Italy

12. Roberto Mabilia, Oncology Unit ‘Rizzoli’ Hospital, Ischia, ASL NA3SUD, Naples, Italy

13. Riccardo Tonachella, Medical Oncology Unit, Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy

14. Antonio Febbraro, Medical Oncology Unit, Fatebenefratelli Hospital, Benevento, Italy

15. Luigi Manzione, Medical Oncology Unit, S. Carlo Hospital, Potenza, Italy

16. Salvatore Palazzo, Medical Oncology Unit, Ospedale Mariano Santo, Cosenza, Italy

17. Gianfranco Filippelli, Medical Oncology, City Hospital, Paola (CS), Italy

18. Bruno Vincenzi, Section of Oncology, Campus Biomedico University, Rome, Italy

19. Enrico Barbato, Medical Oncology Unit, Aversa Hospital, ASLCE, Caserta, Italy

20. Gregorio Cennamo, Medical Oncology Division, ‘San Giovanni di Dio’ Frattamaggiore Hospital, ASLNA2 NORD, Naples, Italy

21. Ferdinando Riccardi, Medical Oncology Unit, AORN Cardarelli, Napoli, Italy

22. Gabriella Misso, Department of Biochemistry & Biophysics, Second University of Naples, Naples, Italy

23. Michele Caraglia, Department of Biochemistry & Biophysics, Second University of Naples, Naples, Italy

24. Raffaele Addeo, Medical Oncology Division, ‘San Giovanni di Dio’ Frattamaggiore Hospital, ASLNA2 NORD, Naples, Italy.

Abstract

ABSTRACT: Aim: We investigated the role of erythropoietin (EPO) in reducing anemia and preventing the development of psychological distress in patients treated with chemotherapy. Patients & methods: This prospective observational study enrolled 591 adult patients receiving EPO at a dose of 30,000 IU administered once weekly for chemotherapy-induced anemia (mean baseline hemoglobin [Hb] level was 9.55 g/dl) over a 12-month period. Results: The majority of patients (371 [71%] patients) achieved a Hb increase >2 g/dl after 4 weeks of treatment. Interestingly, the nonresponder group had a statistically significant deterioration of their psychological conditions as indicated by psychological distress score (p = 0.01). However, within the group of responders to EPO, the Psychological Distress Inventory score remained unchanged. In the present study, severe side effects associated with EPO were not recorded. Conclusion: Hb increase, induced by EPO, ameliorates the psychological conditions of cancer patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.13.161

Reference35 articles.

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2. The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients

4. Fatigue in Patients with Cancers of the Breast or Prostate Undergoing Radical Radiotherapy