Novel oncoprotein EPS8: a new target for anticancer therapy-Reference-Cited by-同舟云学术

Novel oncoprotein EPS8: a new target for anticancer therapy

Published:2013-10 Issue:10 Volume:9 Page:1587-1594
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Li Yu-Hua¹,Xue Tong-Yuan²,He Ying-Zhi³,Du Jing-Wen³

Affiliation:

1. Department of Hematology, Zhujiang Hospital, Southern Medical University, 510282 Guangzhou, China.

2. Second School of Clinical Medicine, Southern Medical University, 510515 Guangzhou, China

3. Department of Hematology, Zhujiang Hospital, Southern Medical University, 510282 Guangzhou, China

Abstract

EPS8 was first identified as a tyrosine kinase substrate, that plays a role in EGFR-mediated mitogenic signaling. Recent research has shown that EPS8 is overexpressed in most types of cancer, for example breast cancer, colon cancer, cervical cancer and even hematologic malignancies. EPS8 is involved in many signaling pathways related to tumorigenesis, proliferation, migration and metastasis, and is a biomarker for poor prognosis of cancer patients. This review aims to provide a comprehensive picture of the role of EPS8 in cellular processes and its significance to tumorigenesis. Furthermore, this review focuses on the potential role of EPS8 as a therapeutic cancer target.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon.13.104

Reference65 articles.

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3. Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6

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