SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome-Reference-Cited by-同舟云学术

SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome

Published:2016-07 Issue:11 Volume:17 Page:1227-1233
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Turolo Stefano¹,Edefonti Alberto¹,Lepore Marta¹,Ghio Luciana¹,Cuzzoni Eva²,Decorti Giuliana²,Pasini Andrea³,Materassi Marco⁴,Malaventura Cristina⁵,Pugliese Fabrizio⁶,Montini Giovanni¹⁷

Affiliation:

1. Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy

2. Università degli Studi di Trieste Dipartimento di Scienze della Vita, Trieste, Friuli-Venezia Giulia, Italy

3. Università degli Studi di Bologna Azienda Ospedaliera Sant/’Orsola-Malpighi, Bologna, Emilia-Romagna, Italy

4. Ospedale Pediatrico Meyer Firenze, Toscana, Italy

5. Università degli Studi di Ferrara, Medical Science Ferrara, Emilia-Romagna, Italy

6. Agenzia sanitaria e sociale regionale Regione Emilia-Romagna, Ravenna, Emilia-Romagna, Italy

7. Università degli Studi di Milano, Department of Clinical Sciences and Community Health, Milan, Italy

Abstract

Aim: of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. Patients & methods: 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution. Results: Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity. Conclusion: The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2016-0029

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