Development of neuro-fuzzy model to explore gene–nutrient interactions modulating warfarin dose requirement-Reference-Cited by-同舟云学术

Development of neuro-fuzzy model to explore gene–nutrient interactions modulating warfarin dose requirement

Published:2016-08 Issue:12 Volume:17 Page:1315-1325
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Pavani Addepalli¹,Naushad Shaik Mohammad²³,Lakshmitha Ganapathy²,Nivetha Sriraman²,Stanley Balraj Alex²,Malempati Amaresh Rao⁴,Kutala Vijay Kumar¹

Affiliation:

1. Department of Clinical Pharmacology & Therapeutics Nizam’s Institute of Medical Sciences, Hyderabad 500082, India

2. School of Chemical & Biotechnology, SASTRA University, Thanjavur – 613401, India

3. Sandor Life Sciences Pvt Ltd, Hyderabad – 500034, India

4. Department of Cardio-Thoracic Surgery, Nizam’s Institute of Medical Sciences, Hyderabad-500082, India

Abstract

Aim: To investigate the influence of alterations in vitamin K (K1, K2 and K3) in modulating warfarin dose requirement. Patients & methods: Reverse phase HPLC to determine the plasma vitamin K; PCR-RFLP to detect polymorphisms; and the neuro-fuzzy model to predict warfarin dose were used. Results: The developed neuro-fuzzy model showed a mean absolute error of 0.000024 mg/week. CYP2C9*2 and CYP2C9*3 mediated warfarin sensitivity was observed when vitamin K is in high and low tertiles, respectively. VKORC1-1639G>A exhibited warfarin sensitivity in all combinations. Higher vitamin K1 was observed in CYP4F2 V433M polymorphism. The requirement of warfarin is low in GGCX 8016 GG genotype compared with GA and AA genotypes. Conclusion: Vitamin K profile along with genetic testing ensures precision in warfarin dose optimization.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2016-0058

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