Acid-sensitive lipidated doxorubicin prodrug entrapped in nanoemulsion impairs lung tumor metastasis in a breast cancer model

Author:

dos Santos Câmara Ana Lygia1,Nagel Gregor2,Tschiche Harald R2,Cardador Camila Magalhães1,Muehlmann Luis Alexandre13,de Oliveira Daniela Mara1,Alvim Paula Queiroz1,Azevedo Ricardo Bentes1,Calderón Marcelo2,Figueiró Longo João Paulo1

Affiliation:

1. Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasília, Brasilia, Brazil

2. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, Berlin 14195, Germany

3. Faculty of Ceilandia, University of Brasilia, Brasilia, Brazil

Abstract

Aim: To develop an acid-sensitive lipidated, doxorubicin (Dox) prodrug (C16-Dox) to be entrapped in lipid nanoemulsion (NE-C16-Dox) as a nanocarrier to treat breast cancer models (in vitro and in vivo). Results: We report the efficacy of NE-C16-Dox in in vitro experiments, as well as the improved chemotherapeutic index and tumor-control efficacy compared with treatment with free Dox in an in vivo murine 4T1 breast cancer model. In addition, NE-C16-Dox allowed the use of a higher dose of Dox, acceptable biocompatibility and a significant reduction in lung metastasis. Conclusion: Taken together, these results indicate that NE-C16-Dox is promising for breast cancer treatment, thus creating possibilities to translate these nanotechnology concepts to clinical applications.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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