Biosynthesized colloidal silver and gold nanoparticles as emerging leishmanicidal agents: an insight

Author:

Ovais Muhammad123,Nadhman Akhtar4,Khalil Ali Talha15,Raza Abida2,Khuda Fazli6,Sohail Muhammad Farhan78,Islam Nazar Ul9,Sarwar Hafiz Shoaib10,Shahnaz Gul10,Ahmad Irshad11,Saravanan Muthupandian12,Shinwari Zabta Khan11213

Affiliation:

1. Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan

2. National Institute for Lasers & Optronics (NILOP), Pakistan Atomic Energy Commission, Islamabad 44000, Pakistan

3. CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China

4. Institute of Integrative Biosciences, CECOS University of IT & Emerging Sciences, Peshawar 25000, Pakistan

5. Department of Eastern Medicine and Surgery, Qarshi University, Lahore, Pakistan

6. Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan

7. Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA

8. Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore 54000, Pakistan

9. Department of Pharmacy, Sarhad University of Science & Information Technology, Peshawar 25000, Pakistan

10. Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan

11. Department of Life Sciences, King Fahd University of Petroleum & Minerals (KFUPM), Dhahran, Saudi Arabia

12. Department of Medical Microbiology & Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia

13. Pakistan Academy of Sciences (PAS), Islamabad 44000, Pakistan

Abstract

Many recent key innovations in nanotechnology have greatly fascinated scientists to explore new avenues in treatment and diagnosis of emerging diseases. Due to extensive utilization of metallic nanoparticles (NPs) in diverse biomedical applications, scientists are looking forward to green synthesis of NPs as safer, simple, fast, and low-cost method over chemical and physical methods. Due to enriched phytochemistry, no need for maintenance and ready availability, plants are preferred for green synthesis of silver (AgNPs) and gold NPs (AuNPs). Recently, several researchers have exploited these biogenic NPs as potential antileishmanial agents. The current article is focused to mechanistically explain the antileishmanial activity of biogenic AuNPs and AgNPs with a futuristic discussion on the faith of these particles as emerging antileishmanial agents.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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