Affiliation:
1. Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Abstract
Self-emulsifying drug–delivery systems (SEDDS) have been widely employed to ameliorate the oral bioavailability of P-glycoprotein (P-gp) substrate drugs and to overcome multidrug resistance in cancer cells. However, the role of formulation aspects in the reduced P-gp activity is not fully understood. In this review, we first explore the role of various SEDDS excipients in the reduced P-gp activity with the main emphasis on the effective excipient concentration range for excipient-mediated modulation of P-gp activity and then we discuss the synergistic effect of various formulation aspects on the excipient-mediated modulation of P-gp activity. This review provides an approach to develop a rationally designed SEDDS to overcome P-gp-mediated drug efflux.
Subject
Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering
Cited by
15 articles.
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