Engineering mechanical microenvironment of macrophage and its biomedical applications

Author:

Li Jing1234,Li Yuhui35,Gao Bin356,Qin Chuanguang4,He Yining7,Xu Feng35,Yang Hui12,Lin Min35

Affiliation:

1. School of Life Sciences, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, PR China

2. Research Center of Special Environmental Biomechanics & Medical Engineering, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, PR China

3. Bioinspired Engineering & Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, PR China

4. Key Laboratory on Space Physics and Chemistry of Ministry of Education and Key Laboratory on Macromolecular Science & Technology of Shanxi Province, Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, 710072, P.R China

5. The Key Library of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P.R. China

6. Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, P.R. China

7. College of Food Science and Engineering, Northwest A & F University Yangling Shaanxi 712100 China

Abstract

Macrophages are the most plastic cells in the hematopoietic system and can be widely found in almost all tissues. Recently studies have shown that mechanical cues (e.g., matrix stiffness and stress/strain) can significantly affect macrophage behaviors. Although existing reviews on the physical and mechanical cues that regulate the macrophage’s phenotype are available, engineering mechanical microenvironment of macrophages in vitro as well as a comprehensive overview and prospects for their biomedical applications (e.g., tissue engineering and immunotherapy) has yet to be summarized. Thus, this review provides an overview on the existing methods for engineering mechanical microenvironment of macrophages in vitro and then a section on their biomedical applications and further perspectives are presented.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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