Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies-Reference-Cited by-同舟云学术

Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies

Published:2018-07 Issue:13 Volume:13 Page:1595-1606
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Taghizadehghalehjoughi Ali¹,Hacimuftuoglu Ahmet²,Cetin Meltem³,Ugur Afife Busra³,Galateanu Bianca⁴,Mezhuev Yaroslav⁵,Okkay Ufuk²,Taspinar Numan²,Taspinar Mehmet⁶,Uyanik Abdullah⁷,Gundogdu Betul⁸,Mohammadzadeh Maryam²,Nalci Kemal Alp²,Stivaktakis Polychronis⁹¹⁰,Tsatsakis Aristidis⁹¹⁰,Jung Tae Woo¹¹,Jeong Ji Hoon¹²,El-Aty AM Abd²¹³

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Veterinary Science, Atatürk University, 25240, Erzurum, Turkey

2. Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240, Erzurum, Turkey

3. Department of Pharmaceutical Technology, Faculty of Pharmacy, Atatürk University, 25240, Erzurum, Turkey

4. Department of Biochemistry and Molecular Biology, 91-95 Splaiul Independentei, 050095, District 5, Bucharest, Romania

5. Center of Biomaterials, D Mendeleev University of Chemical Technology of Russia, Miusskaya Sq. 9, 125047 Moscow, Russia

6. Department of Medical Biology, School of Medicine, Yuzuncu Yil University, Van, Turkey

7. Department of Nephrology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey

8. Department of Pathology, Faculty of Medicine, Ataturk University, 25240, Erzurum, Turkey

9. Laboratory of Toxicology, School of Medicine, University of Crete, 71003, Heraklion, Greece

10. Toxplus SA, University of Crete Spin-Off, 71601, Heraklion, Greece

11. Research Administration Team, Seoul National University Bundang Hospital, Gyeonggi, Republic of Korea

12. Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea

13. Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt

Abstract

Aim: The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model. Methods: The cytotoxic and neurotoxic effects of pure drugs, blank NPs and MET- and IRI-loaded PLGA NPs were investigated in vitro (using methylthiazolyldiphenyl-tetrazolium bromide assay) and in vivo (using Cavalieri's principle for estimation of cancer volume).Results: 1 and 2 mM doses of MET and MET-loaded PLGA NPs, respectively, significantly reduced the volume of extracted cancer. Conclusion: Consequently, MET- and IRI-loaded PLGA NPs may be a promising approach for the treatment of glioblastoma multiforme.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2017-0386

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