Effectiveness and safety of ertapenem used in hospital-at-home units: data from Spanish Outpatient Parenteral Antimicrobial Therapy Registry

Author:

Sanroma Pedro1,Muñoz Pedro2,Mirón-Rubio Manuel3,Aguilera Ana1,Estrada Oriol4,García Dora1,González-Ramallo Víctor J5,Pajarón Marcos1,Sgaramella Giusi A1,González Carmen R1,Mujal Abel6,Abad Aquilino1,Solé Anna7,González Soledad1,Escalada Carmen1,Vitoria Isabel8,Gómez María J8,Parra Juan J9,Sampedro Isabel1,Pereda Iliana1

Affiliation:

1. Hospital-at-Home unit, Valdecilla Hospital, Santander, Spain

2. Teaching unit, Cantabria Health Care Service, Santander, Spain

3. Hospital-at-Home unit, Torrejon Hospital, Torreján de Ardoz, Madrid, Spain

4. Germans Trias i Pujol Hospital, Badalona, Barcelona, Spain

5. Hospital-at-Home unit, Gregorio Marañón University Hospital, Madrid, Spain

6. Hospital-at-Home unit. Department of Internal Medicine. Parc Taulí Hospital Universitari, Sabadell, Spain

7. Arnau de Vilanova University Hospital, Lleida, Spain

8. San Pedro Hospital, Logroño, Spain

9. Family Medicine Resident, Valdecilla Hospital, Santander, Spain

Abstract

Aim: To evaluate the effectiveness and safety of ertapenem in patients hospitalized at home. Patients & methods: Retrospective analysis of data from Spanish Outpatient Parenteral Antimicrobial Therapy (OPAT) registry. Results: Data from 1428 patients (median age 70 years; 5.4% institutionalized) and 1547 infectious processes (24% self-administration) were analyzed. Clinical cure or improvement was achieved in 93.8% of cases. Rate of related readmissions was 4.2%, of clinically important complications -3.9%, and of adverse drug reactions -3.2%. High comorbidity burden, contagion in nursing home and certain types of infection were associated with worse prognosis. Self-administration was effective and safe, except in case of nursing home-acquired infections. Conclusion: Ertapenem OPAT was effective and safe. Caregivers in nursing homes should be better trained in OPAT-related procedures.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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