Proton pump inhibitors versus Cryptococcus species: effects on in vitro susceptibility and melanin production-Reference-Cited by-同舟云学术

Proton pump inhibitors versus Cryptococcus species: effects on in vitro susceptibility and melanin production

Published:2019-04 Issue:6 Volume:14 Page:489-497
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Brilhante Raimunda SN¹,da Rocha Maria G²,de Oliveira Jonathas S¹,España Jaime DA¹,Pereira Vandbergue S¹,SCM Castelo-Branco Débora de¹,A Pereira-Neto Waldemiro de¹,Sidrim José JC¹,A Cordeiro Rossana de¹,Rocha Marcos FG¹²

Affiliation:

1. Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Department of Pathology & Legal Medicine, Federal University of Ceará. Rua Cel. Nunes de Melo, 1315 - Rodolfo Teófilo - CEP: 60430–275, Fortaleza, Ceará, Brazil

2. Postgraduate Program in Veterinary Sciences, College of Veterinary, State University of Ceará. Av. Dr. Silas Munguba, 1700, Campus do Itaperi, CEP: 60714-903, Fortaleza, Ceará, Brazil

Abstract

Aim: This study aimed to evaluate the effects of proton pump inhibitors (PPIs) on growth and melanin production by Cryptococcus spp. Materials & methods: Minimum inhibitory concentrations (MICs) of omeprazole, esomeprazole, rabeprazole, pantoprazole and lansoprazole against Cryptococcus spp. were determined and the effect of PPIs on melanin production was evaluated, in the presence or absence of copper sulfate or glutathione. Results: PPIs showed MICs ranging from 125–1000 μg/ml and decreased melanization by Cryptococcus cells. Addition of copper sulfate or gluthatione restored melanogenesis of cells grown in the presence of PPIs. The presence of PPIs and glyphosate decreased copper sulfate toxicity (1 mM). Conclusion: PPIs inhibited melanogenesis of Cryptococcus spp., possibly by chelating copper or inhibiting copper ATPase transport.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2018-0340

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