SDH2 is involved in proper hypha formation and virulence in Candida albicans-Reference-Cited by-同舟云学术

SDH2 is involved in proper hypha formation and virulence in Candida albicans

Published:2018-08 Issue:10 Volume:13 Page:1141-1156
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Bi Shuang¹,Lv Quan-Zhen¹,Wang Tian-Tian¹,Fuchs Beth Burgwyn²,Hu Dan-Dan¹,Anastassopoulou Cleo G³⁴,Desalermos Athanasios⁴,Muhammed Maged⁴⁵,Wu Chin-Lee⁶,Jiang Yuan-Ying¹,Mylonakis Eleftherios²³,Wang Yan¹²⁴

Affiliation:

1. School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China

2. Division of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, RI 02903, USA

3. Division of Genetics, Cell & Developmental Biology, Department of Biology, University of Patras, Patras, Greece

4. Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA

5. Division of Infectious Diseases, and Division of Gastroenterology, Boston Children's Hospital. Department of Medicine, Department of Adult Inpatient Medicine, Newton Wellesley Hospital, Harvard Medical School, Boston, MA 02115, USA

6. Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA

Abstract

Aim: To investigate the role of SDH2 in Candida albicans filamentation and virulence. Materials & methods: Caenorhabditis elegans and mouse candidiasis models were used to assess the virulence of a sdh2Δ/Δ mutant. Various hypha-inducing media were used to evaluate the hyphal development of C. albicans. DCFH-DA was used to measure intracellular Reactive Oxygen Species (ROS) levels. Results: The sdh2Δ/Δ mutant was avirulent in the C. elegans model, hypovirulent in a murine candidiasis model, and defective to form filaments both in vitro and in vivo. Intracellular ROS level increased in the sdh2Δ/Δ mutant, and the filamentation defects of sdh2Δ/Δ were rescued by decreasing intracellular ROS. Conclusion: SDH2 plays an important role in C. albicans filamentation and virulence probably through affecting intracellular ROS. [Formula: see text]

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2018-0033

Reference41 articles.

1. T2 Magnetic Resonance Assay for the Rapid Diagnosis of Candidemia in Whole Blood: A Clinical Trial

2. Multistate Point-Prevalence Survey of Health Care–Associated Infections

3. Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans

4. Goa1p of Candida albicans Localizes to the Mitochondria during Stress and Is Required for Mitochondrial Function and Virulence

5. The mitochondrial protein Mcu1 plays important roles in carbon source utilization, filamentation, and virulence in Candida albicans

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synergy and Mechanism of Leflunomide Plus Fluconazole Against Resistant Candida albicans: An in vitro Study;Infection and Drug Resistance;2023-06

2. Combined Transcriptome and Metabolome Analysis Reveals That the Potent Antifungal Pyrylium Salt Inhibits Mitochondrial Complex I in Candida albicans;Microbiology Spectrum;2023-04-13

3. Juxtaposing Caenorhabditis elegans-Pathogenic Mould Model with Other Models; How Reliable Is This Nematode Model? A Mini Review;Current Microbiology;2023-02-15

4. iTRAQ-based proteomics revealed baicalein enhanced oxidative stress of Candida albicans by upregulating CPD2 expression;Medical Mycology;2022-09

5. Evaluation of Anti-Candida Potential of Piper nigrum Extract in Inhibiting Growth, Yeast-Hyphal Transition, Virulent Enzymes, and Biofilm Formation;Journal of Fungi;2022-07-27