Genetic diversity and evolutionary features of type VI secretion systems in Salmonella

Author:

Bao Hongxia123,Zhao Jian-Hua123,Zhu Songling123,Wang Shuang4,Zhang Jianjuan123,Wang Xiao-Yu123,Hua Bing123,Liu Chang123,Liu Huidi123,Liu Shu-Lin1235

Affiliation:

1. Systemomics Center, College of Pharmacy & Genomics Research Center, Harbin Medical University, Harbin, PR China

2. HMU-UCCSM Centre for Infection & Genomics, Harbin Medical University, Harbin, PR China

3. Translational Medicine Research & Cooperation Center of Northern China, Heilongjiang Academy of Medical Sciences, Harbin, PR China

4. Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, PR China

5. Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, T2N 1N4, Canada

Abstract

Aim: Type VI secretion systems (T6SS) play key roles in bacterial pathogenesis, but their evolutionary features remain largely unclear. In this study, we conducted systematic comparisons among the documented T6SSs in Salmonella and determined their structural diversity, phylogenetic distribution and lineage-specific properties. Materials & methods: We screened 295 Salmonella genomes for 13 T6SS core components by hidden Markov models and identified 363 T6SS clusters covering types i1, i2, i3 and i4a. Results: Type i3 and i4a T6SSs were restricted to Salmonella enterica subspecies enterica and Salmonella bongori, respectively. whereas type i2 T6SSs were conserved between S. enterica subspecies, arizonae and diarizonae. S. enterica subspecies salamae, indica and houtenae harbored only type i1 T6SSs, which had wide distribution and high sequence diversity. Conclusion: The diverse Salmonella T6SSs have undergone purifying selection pressures during the bacterial evolution and may be involved in host adaptation.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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