Effects of tamoxifen on periodontal disease and Candida albicans of patients with breast cancer and other pathologies

Abstract

Candida albicans is involved in periodontal disease, which is influenced by sex hormones. Aim: To study the effects of the estrogen antagonist tamoxifen (TAM) on periodontal disease of oncological patients; clinical oral strains of C. albicans. Patients: With periodontitis and breast cancer and other with AIDS were used. Materials & methods: Periodontal disease was evaluated by the academy of periodontology procedures and the growth of clinical C. albicans isolates were evaluated by the Clinical and Laboratory Standards Institute techniques. Results: Women who consumed TAM for more than 2 years decreased periodontitis severity. In vitro, TAM inhibited the growth of both fluconazole-sensitive and resistant C. albicans. Conclusion: Administered TAM chronically improves periodontal health and has antifungal activity on oral strains isolated from patients with odontologic and medical pathologies.