Extracellular vesicles derived from mesenchymal cells: perspective treatment for cutaneous wound healing in pediatrics-Reference-Cited by-同舟云学术

Extracellular vesicles derived from mesenchymal cells: perspective treatment for cutaneous wound healing in pediatrics

Published:2018-06 Issue:4 Volume:13 Page:385-394
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Pelizzo Gloria¹,Avanzini Maria Antonietta²,Icaro Cornaglia Antonia³,De Silvestri Annalisa⁴,Mantelli Melissa²,Travaglino Paola²,Croce Stefania²,Romano Piero⁵,Avolio Luigi⁵,Iacob Giulio⁵,Dominici Massimo⁶,Calcaterra Valeria⁷

Affiliation:

1. Pediatric Surgery Unit, Children's Hospital, Istituto Mediterraneo di Eccellenza Pediatrica, Palermo, Italy

2. Immunology & Transplantation Laboratory, Cell Factory, Pediatric Hematology Oncology Unit, Department of Maternal & Children's Health, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy

3. Department of Public Health, Experimental Medicine & Forensic, Histology & Embryology Unit, University of Pavia, Italy

4. Biometry & Clinical Epidemiology, Scientific Direction, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

5. Pediatric Surgery Unit, Department of Maternal & Children's Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

6. Laboratory of Cellular Therapies Department of Medical & Surgical Sciences for Children & Adults University Hospital of Modena & Reggio Emilia, Italy

7. Pediatric Unit, Department of Internal Medicine, University of Pavia & Department of Maternal & Children's Health, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Abstract

Aim: We evaluated the effects of the intradermal injection of extracellular vesicles (EVs) derived from adipose stem cells (ASC-EVs) and bone marrow cells (BM-EVs) in an experimental cutaneous wound repair model. Methods: Mesenchymal stem cells (MSCs) were in vitro expanded from adipose (ASC) or BM tissues (BM-MSC) of rabbits. EVs were separated from the supernatants of confluent ASC and BM-MSCs. Two skin wounds were induced in each animal and treated with MSC or EV injections. Histological examination was performed postinoculation. Results: EV-treated wounds exhibited a better restoration compared with the counterpart MSC treatment. ASC-EV-treated wounds were significantly better than BM-EVs (p = 0.036). Conclusion: EV topical inoculation provides restored architecture during cutaneous wound healing and represents a promising solution for regenerative medicine in children.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2018-0001

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