Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry-Reference-Cited by-同舟云学术

Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry

Published:2015-06 Issue:9 Volume:16 Page:919-928
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Alfirevic Ana¹,Durocher Jill²,Elati Anisa³,León Wilfrido⁴,Dickens David¹,Rädisch Steffen¹,Box Helen¹,Siccardi Marco¹,Curley Paul¹,Xinarianos George¹,Ardeshana Arjun¹,Owen Andrew¹,Zhang J Eunice¹,Pirmohamed Munir¹,Alfirevic Zarko³,Weeks Andrew³,Winikoff Beverly²

Affiliation:

1. The Wolfson Centre for Personalised Medicine, Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Block A, Waterhouse Buildings, 1–5 Brownlow Street, Ashton Street, Liverpool, L69 3GL, UK

2. Gynuity Health Projects, NY, USA

3. Department of Women's & Children's Health, University of Liverpool, Liverpool Women's Hospital, Liverpool, UK

4. Hospital Gineco-Obstétrico Isidro Ayora, Av Colombia N14-66 y Sodiro Quito, Ecuador

Abstract

Aim: Misoprostol, a prostaglandin analogue used for the treatment of postpartum hemorrhage and termination of pregnancy, can cause high fevers. Genetic susceptibility may play a role in misoprostol-induced fever. Subjects & methods: Body temperature of women treated with misoprostol for termination of pregnancy in the UK (n = 107) and for postpartum hemorrhage in Ecuador (n = 50) was measured. Genotyping for 33 single nucleotide polymorphisms in 15 candidate genes was performed. Additionally, we investigated the transport of radiolabeled misoprostol acid across biological membranes in vitro. Results: The ABCC4 single nucleotide polymorphism rs11568658 was associated with misoprostol-induced fever. Misoprostol acid was transported across a blood–brain barrier model by MRP4 and SLCO1B1. Conclusion: Genetic variability in ABCC4 may contribute to misoprostol-induced fever in pregnant women. Original submitted 21 January 2015; Revision submitted 24 April 2015

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs.15.53

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