The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients

Author:

Guest Paul C1,Chan Man K1,Gottschalk Michael G1,Bahn Sabine2

Affiliation:

1. Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge, UK

2. Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands.

Abstract

Schizophrenia is characterized by a wide spectrum of clinical manifestations, including strong effects on mood and behavior. Patients can also suffer from serious comorbidities including immune system or metabolic abnormalities. Recent advances using proteomic profiling approaches have increased our understanding of these molecular effects and have laid the groundwork for unraveling the heterogeneity of this broadly defined disease. These findings could lead to improved diagnosis and stratification of patients through identification of biochemically different disease subtypes and personalized medicine approaches. The inclusion of molecular signatures in psychiatry will be an important leap forward in providing more effective treatment of patients suffering from this debilitating disorder.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

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