Seventeen years of statin pharmacogenetics: a systematic review

Author:

Leusink Maarten12,Onland-Moret N Charlotte2,de Bakker Paul IW23,de Boer Anthonius1,Maitland-van der Zee Anke H1

Affiliation:

1. Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands

2. Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

3. Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

Aim: We evaluated the evidence of pharmacogenetic associations with statins in a systematic review. Methods: Two separate outcomes were considered of interest: modification of low-density lipoprotein cholesterol (LDL-C) response and modification of risk for cardiovascular events. Results: In candidate gene studies, 141 loci were claimed to be associated with LDL-C response. Only 5% of these associations were positively replicated. In addition, six genome-wide association studies of LDL-C response identified common SNPs in APOE, LPA, SLCO1B1, SORT1 and ABCG2 at genome-wide significance. None of the investigated SNPs consistently affected the risk reduction for cardiovascular events. Conclusion: Only five genetic loci were consistently associated with LDL-C response. However, as effect sizes are modest, there is no evidence for the value of genetic testing in clinical practice.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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