Pharmacogenetic considerations in the treatment of gout

Author:

Roberts Rebecca L1,Stamp Lisa K2

Affiliation:

1. Department of Surgical Sciences, Dunedin School of Medicine, Dunedin, New Zealand

2. Department of Medicine, University of Otago Christchurch, PO Box 4345, Christchurch 8140, New Zealand

Abstract

Gout is one of the most common forms of arthritis and the prevalence is increasing. Management comprises rapid and effective control of the inflammation in acute gout and sustained urate lowering in the long term. Improving the outcomes for cheaper old drugs and for the increasing number of new, more expensive agents is an important clinical goal. The role of pharmacogenetics in predicting response and adverse events to gout therapies is of considerable interest. Currently, prospective screening is employed to detect HLA-B*5801 carriage and glucose-6-phosphate dehydrogenase deficiency, to minimize occurrence of allopurinol hypersensitivity and pegloticase-related hemolytic anemia. In the future it is likely that other genetic markers of drug response will make the transition to clinical practice to further improve the efficacy and safety of gout therapies. In this review, we will examine the potential clinical relevance of specific genetic variants in the management of gout.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Therapeutic Strategies for the Treatment of Chronic Hyperuricemia: An Evidence-Based Update;Medicina;2021-01-10

2. Personalized Medicine of Urate-Lowering Therapy for Gout;Recent Advances in Gout;2020-02-26

3. Patient Care Situations Benefiting from Pharmacogenomic Testing;Current Genetic Medicine Reports;2018-04-28

4. Gout;PharmacotherapyFirst: A Multimedia Learning Resource;2017-05

5. ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout;The Pharmacogenomics Journal;2016-01-26

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