Genetic model of endometrial carcinogenesis

Author:

Watari Hidemichi1,Dong Peixin2,Mitamura Takashi3,Fujita Hiromasa4,Sakuragi Noriaki5

Affiliation:

1. Hidemichi Watari is Clinical Associate Professor at the Department of Gynecology, Hokkaido University Hospital (Sapporo, Japan). His research interests focus on the mechanisms of treatment resistance (chemoresistance and radioresistance) in gynecologic malignancies, and the discovery of new therapeutic targets and/or biomarkers to predict therapeutic response.

2. Peixin Dong is an Assistant Professor of Women’s Health Educational System at Hokkaido University. He studies the molecular mechanisms of cancer metastasis, especially the roles of mutant p53 gain of function in endometrial cancer progression and the regulatory effects of miRNAs on epithelial–mesenchymal transition.

3. Takashi Mitamura is part of the medical staff at the Department of Gynecology, Hokkaido University Hospital. His research interests focus on the mechanisms of chemoresistance in ovarian cancer and the discovery of new therapeutic targets and/or biomarkers to predict therapeutic response.

4. Hiromasa Fujita is a Cytopathologist in Hokkaido Cancer Society (Sapporo, Japan). His research focuses on clarifying whether endometrial cytology may be helpful for the diagnosis of early endometrial carcinomas with serous features, including endometrial intraepithelial carcinoma or precancerous lesions (p53 signatures).

5. Noriaki Sakuragi is Head of the Department of Gynecology at Hokkaido University Hospital, and Chair of the Department of Gynecology at Hokkaido University Graduate School of Medicine. His main areas of clinical and research interest focus on gynecological cancers. He and his colleagues have developed and published their technique of an anatomically based nerve-sparing radical hysterectomy for invasive cervical cancer. His expertise also involves endometrial cancer.

Publisher

Future Medicine Ltd

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