Modification of allergen subcutaneous immunotherapy safety precautions and systemic allergic reaction rate reduction

Author:

Mahlab-Guri Keren1ORCID,Mishayev David2ORCID,Yakovlev Marina3ORCID,Asher Ilan1ORCID,Sthoeger Zev1ORCID,Guri Alex4ORCID,Elbirt Daniel1ORCID,Nemet Shay1ORCID,Rosenberg-Bezalel Shira1ORCID

Affiliation:

1. Department of Allergy & Clinical Immunology, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel

2. Faculty of Medicine, Hebrew University of Jerusalem, 9112102, Israel

3. Department of Medicine D, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, 7661041, Israel

4. Department of Pediatrics, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, 7661041, Israel

Abstract

Background: Despite their life-threatening potential, medical team mistakes during subcutaneous immunotherapy are rarely discussed. Real data are missing, and a survey study estimated that dosing errors are responsible for 25% of systemic reactions during immunotherapy. To minimize errors, we modified our safety precautions and compared the rates of systemic allergic reactions before and after the change. Methods: Our retrospective comparative cohort study compared systemic allergic reaction rates during 2012–2015 and 2016–2019, after a second check of the injected allergen/s by another nurse/physician was added to the treatment protocol. Results: The rate of systemic allergic reaction per injection was reduced from 0.93 to 0.71%; p = 0.023. Conclusion: A second check prior to injection is beneficial and can reduce the allergic reaction rate during immunotherapy.

Publisher

Future Medicine Ltd

Subject

Oncology,Immunology,Immunology and Allergy

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