EGFL7 affects the migration of epidermal stem cells in refractory diabetic wounds by regulating Notch signaling pathway-Reference-Cited by-同舟云学术

EGFL7 affects the migration of epidermal stem cells in refractory diabetic wounds by regulating Notch signaling pathway

Published:2023-02 Issue:2 Volume:18 Page:137-153
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Chang Jinyuan¹,Sun Yang¹,Meng Xianxi¹,Zeng Fanglin¹,Wang Xiancheng¹^ORCID

Affiliation:

1. Department of Burn and Plastic Surgery, The Second Xiangya Hospital of Central South University, No. 139, Shaoshan South Road, Furong District, Changsha, Hunan, 410011, China

Abstract

Aim: This study aimed to explore the role of EGFL7 in the healing process of refractory diabetic wounds. Methods: Epidermal stem cells (ESCs) were isolated from healthy mice and diabetic mice, identified by immunofluorescence, transfected with EGFL7 overexpression and silencing lentiviral vectors, and treated with Notch pathway inhibitor (DAPT). Results: SiEGFL7 significantly inhibited the proliferation, invasion and migration of ESCs of healthy mice. DAPT prominently inhibited the expressions of Notch1, Notch2, Hes1 and Jag1 in ESCs of healthy mice induced by overexpressed EGFL7. Overexpressed EGFL7 promoted wound healing in diabetic mice with refractory wounds. Conclusion: EGFL7 affects the proliferation and migration of ESCs in refractory diabetic wounds by regulating the Notch signaling pathway.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2022-0123

Reference48 articles.

1. Models for the study of skin wound healing. The role of Nrf2 and NF-κB

2. The role of surgical revascularization in the management of diabetic foot wounds

3. Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia

4. Synergistic Effect of Bone Marrow-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma in Streptozotocin-Induced Diabetic Rats

5. External Fixation for Surgical Off-Loading of Diabetic Soft Tissue Reconstruction

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