Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice-Reference-Cited by-同舟云学术

Effects of transplantation of umbilical cord blood mononuclear cells into the scrotum on sexual function in elderly mice

Published:2023-09 Issue:9 Volume:18 Page:695-706
ISSN:1746-0751
Container-title:Regenerative Medicine
language:en
Short-container-title:Regenerative Medicine

Author:

Li Jun¹²,Jiang Yinghong²,Xue Wei²,Liu Lejiang²,Yu Hua²,Zhang Xuemei²,Ye Xiao¹,Miao Jianrong¹,Liu Jianling¹,Chen Yueen¹,Lan Xingbin¹,Liu Xiaoqing¹,Yao Wensong¹,Sun Jianchuan¹,Zheng Jing¹,Xiao Jianzhong¹

Affiliation:

1. Medical School, Ningde Normal University, Ningde, 352100, China

2. Medical School, Kunming University, Kunming, 650214, China

Abstract

Aim: This study investigated the effect of allografting umbilical cord blood mononuclear cells (UCBMCs) into the scrotum on sexual function in male elderly mice. Methods: UCBMCs were injected once into the scrotal sheath cavity of elderly mice. Results: The transplanted UCBMCs survived in the scrotal sheath cavity for 1 month. The mice had significantly increased blood testosterone concentrations, cyclic guanosine monophosphate (cGMP) levels and total nitric oxide synthase (T-NOS) activity in the corpus cavernosum and an increase in the number of mouse matings within 30 min (all p = 0.000). Conclusion: Scrotum-implanted UCBMCs improve the sexual function of male elderly mice through testosterone production and the NOS/cGMP pathway, which may provide an innovative transplantation approach for the treatment of erectile dysfunction.

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/rme-2022-0191

Reference70 articles.

1. Lung function impairment and cardiometabolic risks among rural adults: implication for an aging society

2. Are We Ready for the Upcoming Super-Aging Society?

3. The efficacy and safety of acupuncture in the treatment of erectile dysfunction

4. Erectile Dysfunction: AUA Guideline

5. Low-intensity shock wave therapy for the treatment of vasculogenic erectile dysfunction: a narrative review of technical considerations and treatment outcomes