Thoracic radiation therapy could give survival benefit to elderly patients with extensive-stage small-cell lung cancer-Reference-Cited by-同舟云学术

Thoracic radiation therapy could give survival benefit to elderly patients with extensive-stage small-cell lung cancer

Published:2017-06 Issue:13 Volume:13 Page:1149-1158
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

An Changchun¹²,Jing Wang²³,Zhang Yan⁴,Liu Sujing⁵,Wang Haiyong²,Zhu Kunli²,Kong Li²,Guo Hongbo⁶,Zhu Hui²

Affiliation:

1. School of Medicine & Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong Province, China

2. Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, China

3. Department of Radiation Oncology, the First Affiliated Hospital to Zhengzhou University, Zhengzhou, Henan Province, China

4. Department of Medical Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, China

5. Department of Radiation Oncology, Yantai Yuhuangding Hospital, Affiliated Hospital Medical College of Qingdao University, Yuhuangding Rd. 20, Yantai, Shandong Province, China

6. Department of Thoracic Surgery, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, China

Abstract

Aim: To evaluate the effect of thoracic radiation therapy (TRT) in elderly patients (aged ≥65 years) with extensive-stage small-cell lung cancer (ES-SCLC). Patients & methods: This study reviewed the records of 118 elderly patients with ES-SCLC (all with distant metastasis) through January 2006–December 2013. The patients were divided into either a chemotherapy (ChT)/TRT-combination group or a ChT-alone group. Results: The median survival time and 3-year overall survival rates in the ChT/TRT group were significantly higher than those in the ChT-alone group (17.0 vs 11.7 months; 18.1 vs 14.9%; p = 0.014). The 3-year overall survival rates in patients who received prophylactic cranial irradiation were also higher than the rates in patients who did not receive prophylactic cranial irradiation (18.1 vs 5.1%; p = 0.708). Conclusion: TRT combined with ChT could provide a survival benefit to elderly patients with ES-SCLC.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2016-0467

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