The role of mesenchymal stem cells in oncology and regenerative medicine

Author:

Khan Maliha1,Adil Syeda Ezze Rukhshan2,Olson Amanda L3

Affiliation:

1. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

2. Department of Internal Medicine, Dow University of Health Sciences, Karachi, Pakistan

3. Department of Stem Cell Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Abstract

Mesenchymal stem cells (MSCs) have long been used as therapeutic agents in disease affecting various organ systems. However, MSCs are fast emerging as promising anticancer agents which have the potential to treat a number of different cancer types, including glioblastoma and metastatic breast, ovarian and hepatic carcinoma. The ability of MSC to migrate directly into the tumor microenvironment and to produce IFN-α and -β makes this possible. However, the possibility of MSC undergoing either malignant transformation or transformation into protumorigenic fibroblasts currently limits their role in clinical use. It is hoped that future research can overcome these limitations and facilitate the use of MSC clinically.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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