Risk stratification of prostate cancer: integrating multiparametric MRI, nomograms and biomarkers

Author:

Watson Matthew J1,George Arvin K1,Maruf Mahir1,Frye Thomas P1,Muthigi Akhil1,Kongnyuy Michael1,Valayil Subin G1,Pinto Peter A1

Affiliation:

1. Urological Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA

Abstract

Accurate risk stratification of prostate cancer is achieved with a number of existing tools to ensure the identification of at-risk patients, characterization of disease aggressiveness, prediction of cancer burden and extrapolation of treatment outcomes for appropriate management of the disease. Statistical tables and nomograms using classic clinicopathological variables have long been the standard of care. However, the introduction of multiparametric MRI, along with fusion-guided targeted prostate biopsy and novel biomarkers, are being assimilated into clinical practice. The majority of studies to date present the outcomes of each in isolation. The current review offers a critical and objective assessment regarding the integration of multiparametric MRI and fusion-guided prostate biopsy with novel biomarkers and predictive nomograms in contemporary clinical practice.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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