The role of pathology in the management of patients with endometrial carcinoma

Author:

Bartosch Carla1234,Pires Mónica45,Jerónimo Carmen346,Lopes José Manuel278

Affiliation:

1. Department of Pathology, Portuguese Oncology Institute of Porto, Porto, Portugal

2. Department of Pathology and Oncology, Medical Faculty, University of Porto, Porto, Portugal

3. Cancer Biology & Epigenetics Group, Research Center, Portuguese Oncology Institute of Porto, Porto, Portugal

4. Porto Comprehensive Cancer Center (PCCC), Porto, Portugal

5. Department of Gynecology, Portuguese Oncology Institute of Porto, Porto, Portugal

6. Department of Pathology & Molecular Immunology, Institute of Biomedical Sciences Abel Salazar-ICBAS, University of Porto, Porto, Portugal

7. Department of Pathology, Centro Hospitalar de São João, Porto, Portugal

8. IPATIMUP (Institute of Molecular Pathology & Immunology, University of Porto) & I3S – Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal

Abstract

Pathology plays a critical role in every step in the management of endometrial carcinoma patients. In this review, we describe the state of the art of pathological examination, including examination of endometrium biopsy; intra-operative evaluation with gross examination and frozen section; and grossing of hysterectomy specimen and its histological and immunohistochemistry study. The main pathologic findings in each step are described, as well as limitations and difficulties that may ensue. We highlight the important pathologic parameters that determine treatment options and prognosis of endometrial cancer patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Reference100 articles.

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