The emerging role of obesity, diet and lipid metabolism in prostate cancer-Reference-Cited by-同舟云学术

The emerging role of obesity, diet and lipid metabolism in prostate cancer

Published:2017-02 Issue:3 Volume:13 Page:285-293
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Ferro Matteo¹,Terracciano Daniela²,Buonerba Carlo³,Lucarelli Giuseppe⁴,Bottero Danilo¹,Perdonà Sisto⁵,Autorino Riccardo⁶,Serino Alessandro¹,Cantiello Francesco⁷,Damiano Rocco⁷,Andras Iulia⁸,De Placido Sabino³,Di Lorenzo Giuseppe³,Battaglia Michele⁴,Jereczek-Fossa Barbara A⁹¹⁰,Mirone Vincenzo¹¹,De Cobelli Ottavio¹⁸¹²

Affiliation:

1. Department of Urology, European Institute of Oncology (IEO), Milan, Italy

2. Department of Translational Medical Sciences, University ‘Federico II', Naples, Italy

3. Department of Clinical Medicine & Surgery, Oncology Division, University Federico II, Naples, Italy

4. Department of Emergency & Organ Transplantation – Urology, Andrology & Kidney Transplantation Unit, University of Bari, Bari, Italy

5. Department of Urology, National Cancer Institute of Naples, Naples, Italy

6. Urology Institute, University Hospitals Case Medical Center, Cleveland, OH 44106, USA

7. Division of Urology, Magna Graecia University of Catanzaro, Catanzaro, Italy

8. UMF Iuliu Hatieganu, Cluj-Napoca, Romania

9. Division of Radiation Oncology, European Institute of Oncology, Milan, Italy

10. Department of Oncology & Hemato-oncology, University of Milan, Milan, Italy

11. Department of Neurosciences, Sciences of Reproduction & Odontostomatology, University Federico II of Naples, Via Sergio Pansini, 80131 Naples, Italy

12. University of Milan, Milan, Italy

Abstract

Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2016-0217

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