Ipilimumab: from preclinical development to future clinical perspectives in melanoma-Reference-Cited by-同舟云学术

Ipilimumab: from preclinical development to future clinical perspectives in melanoma

Published:2017-03 Issue:7 Volume:13 Page:625-636
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Letendre Paul¹,Monga Varun¹,Milhem Mohammed¹,Zakharia Yousef¹

Affiliation:

1. Department of Hematology, Oncology & Blood & Marrow Transplantation & the Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA

Abstract

The arsenal for the treatment of metastatic melanoma is limited. A new approach to therapy using checkpoint blockade has improved overall survival in this patient population. Ipilimumab a CTLA-4 monoclonal antibody is a first in class drug that has pioneered this revolution. In this review, the authors provide an account of the different stages that led to the development of ipilimumab, its approval in the clinical setting for the treatment of advanced melanoma and ongoing investigations of combinatorial immune therapy.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2016-0385

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