HBV-related hepatocellular carcinoma: the role of integration, viral proteins and miRNA-Reference-Cited by-同舟云学术

HBV-related hepatocellular carcinoma: the role of integration, viral proteins and miRNA

Published:2012-12 Issue:12 Volume:7 Page:1237-1249
ISSN:1746-0794
Container-title:Future Virology
language:en
Short-container-title:Future Virology

Author:

Lim Lucy¹²,Tran Bang Manh¹³,Vincan Elizabeth¹³,Locarnini Stephen¹,Warner Nadia⁴

Affiliation:

1. Victorian Infectious Diseases Reference Laboratories, North Melbourne, Victoria, Australia

2. Austin Liver Transplant Unit, Heidelberg, Victoria, Australia

3. Cancer Biology Laboratory, Department of Anatomy & Neuroscience, The University of Melbourne, Parkville, Victoria, Australia

4. Victorian Infectious Diseases Reference Laboratories, North Melbourne, Victoria, Australia.

Abstract

The development of hepatocellular carcinoma during chronic hepatitis B infection is a multifactorial process thought to be a consequence of several direct and indirect mechanisms. In this review we discuss how viral proteins and cycles of ongoing liver damage and regeneration, coupled with HBV DNA integration and aberrant miRNA expression may enhance the risk for the development of hepatocellular carcinoma.

Publisher

Future Medicine Ltd

Subject

Virology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fvl.12.113

Reference154 articles.

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