Prognostic implications of depression and inflammation in patients with metastatic lung cancer

Author:

McFarland Daniel C1ORCID,Saracino Rebecca M.1,Miller Andrew H.2,Breitbart William1,Rosenfeld Barry3,Nelson Christian1

Affiliation:

1. Department of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA

2. Department of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA

3. Department of Psychology, Fordham University, Bronx, NY 10458, USA

Abstract

Background: Lung cancer-related inflammation is associated with depression. Both elevated inflammation and depression are associated with worse survival. However, outcomes of patients with concomitant depression and elevated inflammation are not known. Materials & methods: Patients with metastatic lung cancer (n = 123) were evaluated for depression and inflammation. Kaplan–Meier plots and Cox proportional hazard models provided survival estimations. Results: Estimated survival was 515 days for the cohort and 323 days for patients with depression (hazard ratio: 1.12; 95% CI: 1.05–1.179), 356 days for patients with elevated inflammation (hazard ratio: 2.85, 95% CI: 1.856–4.388), and 307 days with both (χ2 = 12.546; p < 0.001]). Conclusion: Depression and inflammation are independently associated with inferior survival. Survival worsened by inflammation is mediated by depression-a treatable risk factor.

Funder

Loan Repayment Program-National Institutes of Health

Memorial Sloan-Kettering Cancer Center

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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