Real-world use and acceptance of rituximab biosimilars in non-Hodgkin lymphoma in an oncologist network in Germany

Author:

Otremba Burkhard1,Borchardt Jens2,Kuske Andra3,Hollnagel-Schmitz Maike3,Losch Florian O3

Affiliation:

1. Onkologische Praxis Oldenburg/Delmenhorst, Oldenburg, Germany

2. Onkotrakt AG, Hamburg, Germany

3. Medical Oncology, Hexal AG, Holzkirchen, Germany

Abstract

Aim: Present real-world data for rituximab (biosimilar and reference)-containing regimens in extrapolated indications in non-Hodgkin lymphoma (NHL)/chronic lymphocytic leukemia (CLL). Patients & methods: Data collected from office-based oncologic practices in Germany (July 2017–June 2019). Results: Of 1741 patients, 1241 had NHL; 500 had CLL. Of 7595 therapy cycles, 28.3% used reference rituximab; 55.2% used rituximab biosimilars; 2.0% used subcutaneous rituximab; 14.5% used rituximab, not otherwise specified. Rituximab biosimilars were used across all indications; 57.3% of cycles were administered in extrapolated indications. Over 24 months, the proportion of rituximab prescriptions that were for biosimilars increased from 12.0 to 83.0%. Conclusion: Our real-world data in NHL and CLL depicts increasing use of rituximab biosimilars across multiple treatment protocols, including extrapolated indications.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Reference40 articles.

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3. EMA. Truxima EPAR (2016).

4. Rituximab biosimilars open new horizons in immunotherapy

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